MicroRNAs as Possible Biomarkers for Diagnosis and Therapy of Alzheimer’s Disease by Regulating the Abnormal Expression of Genes Related to Tau

Alzheimer’s disease (AD), the most common dementia with symptom of deterioration memory and cognitive functions, becomes one prevalent threats globally. Tau hyperphosphorylation is major risk factors AD. At present, there no effective treatment or quick diagnostic methods for pre-clinical stage this disease. MicroRNAs (miRNAs) are small (20-25bp) non-coding, double stranded RNA molecule. They mainly regulate gene expression during post-transcription by binding to 3-’UTR mRNA then stop translation. Unlike other biomarkers using disease, miRNAs stable widely found in body fluids such as serum, tissues, Cerebrospinal fluid (CSF) miRNA can multiple genes. As a result, they potentially used diagnosis therapeutic many diseases including Currently, field that has been rapidly developed. To examine mechanism function potential AD, review summarizes current techniques comparing several microRNAs especially regulating tau toxicity practicable agents. It likely detect different stages reduce if carries forward.